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ORPHENADRINE HYDROCHLORIDE

Product Name
ORPHENADRINE HYDROCHLORIDE
CAS No.
341-69-5
Chemical Name
ORPHENADRINE HYDROCHLORIDE
Synonyms
BF 5930;BG 5930;BS 5930;Mebedrol;Mephenamin;Brocasipal;Mephenamine;Brocadisipal;mephenaminforte;Mephenamin forte
CBNumber
CB6782740
Molecular Formula
C18H24ClNO
Formula Weight
305.84
MOL File
341-69-5.mol
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ORPHENADRINE HYDROCHLORIDE Property

Melting point:
159.0 to 164.0 °C
Boiling point:
-195 °C
Density 
0.295 g/cm3
storage temp. 
2-8°C
solubility 
Freely soluble in water and in ethanol (96 per cent).
color 
Crystals
BRN 
3745818
Stability:
Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference
341-69-5(CAS DataBase Reference)
EPA Substance Registry System
Orphenadrine hydrochloride (341-69-5)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
RIDADR 
3249
WGK Germany 
3
RTECS 
KR6300000
HazardClass 
6.1(b)
PackingGroup 
III
Toxicity
LD50 oral in rat: 255mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
Y0000100
Product name
Orphenadrine hydrochloride
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000100
Price
$150
Updated
2024/03/01
Sigma-Aldrich
Product number
75517
Product name
Orphenadrine hydrochloride
Purity
99%
Packaging
5g
Price
$64.2
Updated
2024/03/01
Cayman Chemical
Product number
26391
Product name
Orphenadrine (hydrochloride)
Packaging
10mg
Price
$49
Updated
2024/03/01
Cayman Chemical
Product number
26391
Product name
Orphenadrine (hydrochloride)
Packaging
25mg
Price
$115
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0001181
Product name
Orphenadrine for peak identification
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0001181
Price
$203
Updated
2024/03/01
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ORPHENADRINE HYDROCHLORIDE Chemical Properties,Usage,Production

Chemical Properties

White or almost white, crystalline powder.

Uses

Antihistaminic;H1 antogonist

Definition

ChEBI: A hydrochloride comprising equimolar amounts of ophenadrine and hydrogen chloride.

General Description

Odorless white or almost white crystalline powder. pH (aqueous solution) about 5.5. Bitter numbing taste.

Air & Water Reactions

May be sensitive to prolonged exposure to light and air. Water soluble.

Reactivity Profile

ORPHENADRINE HYDROCHLORIDE is incompatible with strong oxidizers.

Fire Hazard

Flash point data for ORPHENADRINE HYDROCHLORIDE are not available; however, ORPHENADRINE HYDROCHLORIDE is probably combustible.

Biochem/physiol Actions

Muscarinic receptor antagonist; H1 histamine receptor antagonist; muscle relaxant. Orphenadrine has also been reported to inhibit the noradrenergic transporter and to block the NMDA receptor ion channel.

Clinical Use

Anti-muscarinic:
Parkinsonism
Drug induced extra-pyramidal symptoms

Safety Profile

Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects: mydriasis @updlaryd ilation), hallucinations, distorted perceptions, pulse rate increase, intracranial pressure increase. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl

Metabolism

Orphenadrine is almost completely metabolised to at least 8 metabolites in the liver.
It is mainly excreted in the urine as metabolites and small amounts of unchanged drug

ORPHENADRINE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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ORPHENADRINE HYDROCHLORIDE Suppliers

Belgium 1 China 64 France 1 Germany 3 India 15 Italy 2 Japan 1 South Korea 1 Switzerland 2 The Netherlands 1 United Kingdom 4 United States 19 Venezuela 1 Global 115
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View Lastest Price from ORPHENADRINE HYDROCHLORIDE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Orphenadrine hydrochloride 341-69-5
Price
US $1.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2020-01-08

341-69-5, ORPHENADRINE HYDROCHLORIDERelated Search:

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  • 341-69-5
  • C18H23NOHCl
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  • Amine Salts
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  • Organic Building Blocks
  • API